Enhancing the efficacy of ulcerative colitis treatment by inhibiting LCN2-mediated pyroptosis through traditional processing techniques: With the rhizome of Atractylodes macrocephala Koidz. as an example

Anran Zhang

doi:10.1016/j.jep.2026.122037

Ethnopharmacological investigation of Elaeocarpus sylvestris leaf extract in mitigating atopic dermatitis-like lesions via inflammatory signaling modulation

2026-06-18

0

PRE

AI

S

So-Yeon Kim

Y

Young-Ju Do

S

Su-Jung Lee

Y

Ye Eun Cho

S

So-Young Cho

Y

Ye-Won Lee

S

Seon-Woo Lee

N

Na-Hyun Lee

J

Ji-Yeong Bae

S

Sanghyun Lee

S

Sang Ho Lee *

S

Se Jin Park *

DOI：10.1016/j.jep.2026.122079

Original

Original request for help

Save

Abstract

En 中文

• Elaeocarpus sylvestris exhibits anti-inflammatory activity in LPS-stimulated keratinocytes. • Geraniin was identified as a major constituent of ESLE by HPLC analysis. • ESLE modulates MAPK, NF-κB, and JAK/STAT signaling, indicating its role in inflammatory responses. • ESLE alleviates AD-like symptoms, suggesting improved skin barrier function in vivo. • This study provides pharmacological evidence supporting the traditional use of E. sylvestris in skin inflammation.

Ethnopharmacological investigation of Elaeocarpus sylvestris leaf extract in mitigating atopic dermatitis-like lesions via inflammatory signaling modulation

Abstract

Journal

Organization

Cited Papers

Citing Papers