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Ethyl acetate as solvent for the synthesis of poly(2-ethyl-2-oxazoline)
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DOI：10.1039/c9gc03872h.png)
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Abstract
En 中文
Poly(2-ethyl-2-oxazoline) (PEtOx) is the most common poly(2-oxazoline) for biomedical applications resulting from its high water-solubility, good commercial availability and well-controlled polymerization. In this article, we report the polymerization of 2-ethyl-2-oxazoline (EtOx) in ethyl acetate to replace the current state-of-the-art polymerization of EtOx in acetonitrile and chlorobenzene. This switch towards ethyl acetate as green solvent is an important improvement towards pharmaceutical compliance/compatibility, besides the lower burden for the environment.
Keywords:
RING-OPENING POLYMERIZATION
CYCLIC IMINO ETHERS
IN-VITRO
GENE DELIVERY
2-ETHYL-2-OXAZOLINE
POLY(2-OXAZOLINE)S
IMINOETHERS
CHEMISTRY
FILMS
PEI
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