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Etomidate relieves oxaliplatin-induced neuropathic pain by regulating AMPK/Nrf2/HO-1 axis

delete2026-04-03
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PRE
AI
K
Kexin Chen
Y
Yuchao Lin
X
Xuechang Han
L
Lei Zhao
J
Jing Wang
Y
Yu Li *
DOI：10.1016/j.mce.2026.112791delete
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Abstract

Abstract

En 中文
• Eto alleviates OXA-induced neuropainful behaviors; • Eto mitigates OXA-induced spinal cord inflammation; • Eto relieves OXA-induced oxidative stress response in spinal cord tissues; • Eto activates AMPK/Nrf2/HO-1 pathways in spinal cord tissue of OXA treated mice; • Eto reduces inflammation and oxidative stress in C6 cells model by regulating AMPK/Nrf2/HO-1 pathway.
Keywords:
Etomidate
Oxaliplatin-induced neuropathic pain
AMPK/Nrf2/HO-1 pathway
Spinal cord inflammation
Oxidative stress

Journal

Molecular and Cellular Endocrinology cover
Molecular and Cellular Endocrinology
IF:
3.6
Papers:
8.0K
Citations:
1.6W

Organization

H
Henan University of Science and Technology
Scholars:
2.9K
Papers: 814
Citations: 1.0K
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