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Evaluating the efficacy and safety of tezepelumab in the treatment of chronic rhinosinusitis with nasal polyps
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DOI：10.1080/1750743X.2025.2567844.png)
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Abstract
En 中文
Chronic rhinosinusitis with nasal polyps (CRSwNP) is a debilitating inflammatory disease associated with high recurrence rates and limited response to current therapies. Tezepelumab, a human monoclonal antibody targeting thymic stromal lymphopoietin (TSLP), has emerged as a promising upstream biologic intervention. In the phase 3 WAYPOINT trial, tezepelumab significantly reduced nasal polyp score (−2.07), nasal congestion severity (−1.03), and SNOT-22 scores (−28.4), while decreasing the need for endoscopic sinus surgery by 98% versus placebo. Post hoc analyses of the NAVIGATOR trial showed SNOT-22 improvements (−21.06 vs −10.48 placebo), and PATHWAY data confirmed reductions in asthma exacerbations (up to 85%) and suppression of type 2 inflammatory biomarkers including eosinophils, FeNO, IL-5, and IL-13. Tezepelumab demonstrated a favorable safety profile without increased risk of serious infection or hypersensitivity. Although not approved for CRSwNP, tezepelumab is a promising investigational agent for patients with corticosteroid-refractory or biologic-insensitive disease. Ongoing trials such as ESSENCE will clarify its long-term efficacy, safety, and positioning relative to existing monoclonal antibodies.
Keywords:
Chronic rhinosinusitis with nasal polyps
tezepelumab
biologic therapy
SNOT-22
endoscopic sinus surgery
asthma comorbidity
Journal
J
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2.1K
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