Evaluation of Escherichia coli as a prophylactic treatment of intestinal colonization by ESBL-producing E. coli in a murine model of antibiotic-induced dysbiosis

Murad Ishnaiwer

doi:10.1093/jambio/lxag041

Evaluation of Escherichia coli as a prophylactic treatment of intestinal colonization by ESBL-producing E. coli in a murine model of antibiotic-induced dysbiosis

2026-02-06

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M

Murad Ishnaiwer *

M

Michel Pierre Dion

E

Emmanuel Montassier

Q

Quentin Le Bastard

E

Eric Batard

DOI：10.1093/jambio/lxag041

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Abstract

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Intestinal colonization by multidrug-resistant (MDR) Enterobacteriaceae represents a major public health concern as it can lead to difficult-to-treat infections, environmental contamination, and transmission. This study evaluated the efficacy of a prophylactic treatment using Escherichia coli strains isolated from murine feces (comEc) to reduce intestinal colonization by extended-spectrum beta-lactamase-producing E. coli (ESBL-E. coli) in a murine model of antibiotic-induced dysbiosis.

Keywords:

Escherichia coli

ESBL-producing E. coli

intestinal colonization

prophylactic treatment

antibiotic-induced dysbiosis

Evaluation of Escherichia coli as a prophylactic treatment of intestinal colonization by ESBL-producing E. coli in a murine model of antibiotic-induced dysbiosis

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