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Evaluation of the effect of different intermittent fasting regimens on metabolic parameters in healthy male Wistar rats
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DOI：10.1017/S0007114525106120.png)
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Abstract
En 中文
This study aimed to evaluate the influence of different intermittent fasting regimens on metabolic parameters in healthy rats and compare them with caloric restriction. A total of fifty adult male Wistar rats (±90 days old) were randomised into 5 groups: control group (CON); caloric restriction group (CR); time-restricted feeding group (TRF); alternate-day fasting (ADF) group and alternate-day modified fasting group (ADMF). ADF and ADMF stood out for improving the metabolic parameters in healthy rats by presenting improvements in glucose parameters; greatest weight loss (ADF v. CON: −16·50 (sd 6·16) g; effect size = −5·34; 95 % CI: −7·05; −3·04; P < 0·001; ADMF v. CON: –21·88 (sd 6·66) g; effect size = −5·83; 95 % CI: −7·66; −3·36; P < 0·001) and higher HDL (ADF v. CON: 141·50 (sd 10·17) mg/dl; effect size = 3·03; 95 % CI: 1·01; 4·45; P < 0·001; ADMF v. CON: 133·10 (sd 5·94) mg/dl; effect size = 3·37; 95 % CI: 1·22; 4·86; P = 0·004). Additionally; ADMF presented a smaller adipocyte area among the fasting regimens (13·92 (sd 2·06) area/µm2; effect size = −4·20; 95 % CI: −5·45; −2·66; P < 0·001 v. CON); in addition to presenting muscle fibre hypertrophy (71·20 (sd 5·16) area/µm2; effect size = 2·93; 95 % CI: 1·57; 4·05; P < 0·001 v. CON); followed by ADF (adipocyte area: 19·25 (sd 0·87) area/µm2; effect size = −2·19; 95 % CI: −3·12; −1·12; P = 0·003 v. CON; muscle fibre: 53·80 (sd 6·61) area/µm2; effect size = 2·93; 95 % CI: 1·57; 4·05; P = 0·566 v. ADMF). The ADF and ADMF groups were more effective among the intermittent fasting regimens analysed in promoting improvements in metabolic parameters in healthy rats.
Keywords:
Adiposity
Alternate-day fasting
Caloric restriction
Liver parameters
Modified fasting
Muscle
Time-restricted feeding
alternate-day fasting
alternate-day modified fasting
control
caloric restriction
glucose tolerance test
high-intensity lipoprotein
homeostasis model for insulin resistance
homeostasis model for β-cell function
low-intensity lipoprotein
intermittent fasting
insulin tolerance test
ITT glucose decay percentage constant
principal component analysis
triacylglycerols
total cholesterol
time-restricted feeding
very low-density lipoprotein
Journal
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3
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1.0W
Citations:
2.8W
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Cited Papers