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Evaluation of Triple Antibiotic Paste-modified Soft Liner on Antibacterial Activity and Wound Healing Following Dental Implant Placement: A Prospective Interventional Study
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DOI：10.7860/JCDR/2026/82354.22705.png)
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Abstract
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Introduction: Soft liners used in temporary prostheses during implant healing may harbour microbial biofilms, potentially impairing peri-implant tissue health. Incorporating antimicrobial agents into these liners could reduce bacterial colonisation and promote early wound healing. Aim: To evaluate and compare the antibacterial activity and wound healing potential of a Triple Antibiotic Paste (TAP)-Modified Soft liner (TMS) versus a conventional soft liner in patients undergoing dental implant placement. Materials and Methods: This prospective interventional study was conducted at the Department of Implantology, Saveetha Dental College and Hospital, Chennai, India, between April 2024 and July 2024. It included 40 systemically healthy participants with a single missing tooth and was randomly assigned into two equal groups. Group 1 (Control) received a conventional soft liner in a temporary partial denture post-implant placement, while Group 2 (Test) received TMS in the same prosthesis. Antibacterial activity was assessed on days 0, 3, and 7 against Streptococcus aureus, Pseudomonas aeruginosa, and Enterococcus faecalis using the agar well-diffusion method. Wound healing was evaluated on days 7 and 14 using the Landry Wound Healing Index (WHI). Statistical analysis was performed using IBM Statistical Package for Social Sciences (SPSS) software, version 23.0 (Armonk, NY, USA), utilising an Independent t-tests, with significance set at p-value <0.05. Results: The mean age of participants in the control group was 44.7 +/- 8.1 years, while the test group had a mean age of 45.3 +/- 7.5 years, with no statistically significant difference between the groups (p-value=0.78). Group 2 (TMS) demonstrated significantly larger zones of inhibition for all three test organisms on days 0, 3, and 7 (p-value <0.05), indicating superior and sustained antibacterial activity. Wound healing scores were significantly higher in group 2 at both day 7 (3.20 +/- 0.63 vs 2.00 +/- 0.82; p-value=0.002) and day 14 (4.70 +/- 0.48 vs 3.20 +/- 0.63; p-value <0.001), reflecting enhanced tissue healing. Conclusion: TMS demonstrated superior antibacterial activity and enhanced early wound healing compared to conventional liners, indicating their potential as a bioactive adjunct to improve peri-implant healing. Further long-term studies are needed to confirm these findings.
Keywords:
Dental prosthesis
Drug delivery systems
Peri-implant health
Tissue conditioners
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