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Evidence of skull bone translocator protein overexpression linked to multiple sclerosis progression
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DOI：10.1093/brain/awag084.png)
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Abstract
En 中文
The skull bone marrow contributes to brain immune homeostasis via recently discovered skull-meningeal channels, enabling the bidirectional trafficking of immune cells between skull bone and underlying dura mater. In multiple sclerosis, autoreactive T cells migrate to the bone marrow and shift its hematopoietic output toward myeloid differentiation, contributing to disease progression. However, the role of the skull bone marrow in multiple sclerosis pathophysiology, and its relationship to brain damage and clinical disability remain largely unexplored.
Keywords:
skull bone marrow
multiple sclerosis
immune homeostasis
translocator protein
neuroinflammation
Journal
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11.7
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