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Evolving complex insulation
DOI:10.1038/s41589-021-00873-9.png)
Abstract
En 中文
Prokaryotic genomes are rife with highly similar toxin-antitoxin modules that need to be protected and diversified at the same time. Studies of paralogous modules now reveal how evolution secures insulation between related systems, without compromising toxin inhibition.
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Journal
IF:
13.7
Papers:
4.8K
Citations:
3.3W
Organization
Cited Papers
Activity of acetyltransferase toxins involved in Salmonella persister formation during macrophage infection
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Auxiliary interfaces support the evolution of specific toxin-antitoxin pairing
NATURE CHEMICAL BIOLOGY
IF13.7
Distinct oligomeric structures of the YoeB-YefM complex provide insights into the conditional cooperativity of type II toxin-antitoxin system
NUCLEIC ACIDS RESEARCH
IF13.1
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