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Exosome-Encapsulated CuPt-S Hybrid Nanoclusters: Triple Enzyme Activities for Cuproptosis-Enhanced Low-Dose Radiotherapy

delete2026-05-08
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PRE
AI
H
Han Tang
M
Meng Lyu
全
全红 (Hong Quan) *
Z
Zhi Jie Tan
DOI：10.1016/j.colsurfb.2026.115796delete
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Abstract

Abstract

En 中文
• Innovative synthesis of EM-CPS nanoclusters for inducing cuproptosis via low-dose RT. • Sulfur hybridization generates abundant ion pairs while enhancing triple enzymatic activity. • Exosome coating improves biocompatibility, tumor accumulation, and reduces off-target cytotoxicity. • In vivo studies demonstrate potent tumor suppression, robust immune activation effect, and excellent biosafty.
Keywords:
Cuproptosis
Low-dose radiotherapy
Exosome-encapsulated nanoclusters
Triple enzymatic activity
Tumor suppression

Journal

C
Colloids and Surfaces B: Biointerfaces
IF:
5.6
Papers:
1.4W
Citations:
4.2W

Organization

H
huazhong university of science and technology
Scholars:
2.3W
Papers: 7.2K
Citations: 5
W
wuhan university
Scholars:
7.8W
Papers: 5.7W
Citations: 70
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