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Exosome-mediated scutellarin delivery enhances BBB penetration and microglia targeting in antiviral neuroprotection
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DOI：10.1016/j.biopha.2025.118903.png)
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Abstract
En 中文
• Brain-derived exosomes were isolated for targeted scutellarin delivery to the CNS. • Exosomes loaded with scutellarin (Exos-Scu) enhanced BBB penetration by 3-fold. • Exos-Scu effectively targeted microglia and promoted anti-inflammatory M2 polarization. • Exos-Scu inhibited PRV-induced neuroinflammation and viral replication in vitro. • This system offers a novel strategy for delivering drugs to treat neuroinflammation.
Keywords:
Exosomes
Scutellarin
Blood-brain barrier
Drug delivery
Microglial polarization
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