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Exosomes from joints mediate depressive-like behaviors in MIA arthritis mice
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DOI：10.1016/j.brainresbull.2026.111929.png)
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Abstract
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• Joint-derived exosomes from MIA knees induce depressive-like behavior in mice • Exosomes carry surface HMGB1 that crosses the BBB and triggers brain senescence • Blocking exosome release with GW4869 prevents depressive-like and aging phenotypes • Neutralizing exosomal HMGB1 with 2G7 reverses brain senescence and anhedonia • HMGB1 exosomes activate neuronal NF-κB and promote microglial pro-inflammation state polarization
Keywords:
MIA
Exosome
HMGB1
depressive-like behavior
Senescence
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