Exploring the Genetic Underpinnings of DTI-ALPS: A Genome-Wide Correlation Study and Implications for Brain Health

2025-09-12

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Jiancheng Wu

D. M. Xiong

Xinyu Wang

Ruihua Zhu

Nana Liu

Z. Wang

Xingyu Zhang

Meng Cheng

Zhixuan Liu

Siqi Wang

Qiang Xu

Jiayuan Xu

Junping Wang

DOI：10.1016/j.bpsc.2025.09.002

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Glymphatic system (GS) plays a central role in eliminating metabolic waste from human brain. Diffusion tensor image analysis along the perivascular space (ALPS) has emerged as a non-invasive biomarker for evaluating GS function. While decreased ALPS is consistently linked to impaired GS in various central nervous system (CNS) pathologies, the genetic architectures and neural mechanisms underlying ALPS and its role in maintaining brain health remain unknown.

Exploring the Genetic Underpinnings of DTI-ALPS: A Genome-Wide Correlation Study and Implications for Brain Health

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