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Exposing relationships using directed evolution

delete2004-05-01
delete3
PRE
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O
Oliver J. Miller
P
Paul A. Dalby
DOI：10.1016/j.tibtech.2004.03.003delete
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Abstract

Abstract

En 中文
Functionally related protein structures that have undergone significant mutagenesis and re-arrangement over a large evolutionary time-scale might no longer share enough sequence or structural similarity to be revealed by even the most advanced database searches. Recently, Christ and Winter used directed evolution to obtain functional variants of the RNA-hairpin-binding protein Rop. Using the functional sequences obtained, a structural database search revealed previously unknown similarity to the tRNA-binding region of valy- tRNA synthetase.
Keywords:
IN-VITRO EVOLUTION
BINDING-PROTEINS
PHAGE DISPLAY
ENZYME
AFFINITY
RECOGNITION
STABILITY
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Journal

Trends in Biotechnology cover
Trends in Biotechnology
IF:
14.9
Papers:
3.8K
Citations:
2.0W

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