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Extracellular vesicle secretome from mesenchymal stromal cells prevents post-ischemic heart failure by targeting cardiac fibrosis
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DOI：10.1016/j.stem.2026.07.003.png)
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Abstract
En 中文
• GMP-compatible production enables translation of MSC-EV therapy • MSC-EVs reduce myofibroblast activation and preserve LVEF in mice • Intracoronary MSC-EVs confer acute cardioprotection in pigs • PDGFRβ-PET enables monitoring of post-infarction fibrotic activity in patients
Keywords:
extracellular vesicles
mesenchymal stromal cells
secretome
myocardial ischemia-reperfusion injury
cardioprotection
macrophage polarization
myofibroblasts
cardiac fibrosis
heart failure
positron emission tomography
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