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Fabrication of a ternary β-cyclodextrin/curcumin/methotrexate compound for drug co-delivery, cytotoxicity and cell phagocytosis
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DOI：10.1016/j.molstruc.2026.146073.png)
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Abstract
En 中文
This study investigates the drug co-delivery, cytotoxicity and cell phagocytosis of the ternary compound of (3-CD/ CUR/MTX prepared via co-precipitation methods. Fourier-transform infrared spectroscopy (FTIR), powder X-ray diffraction (XRD), 1H NMR and thermogravimetric analysis (TGA) confirmed the successful encapsulation of CUR and MTX. Scanning electron microscopy (SEM) revealed rock-like morphologies for (3-CD, (3-CD/MTX, and (3-CD/ CUR/MTX. While (3-CD/CUR exhibited micro-scaled rod structures. Thermogravimetric analysis (TGA) indicated that the compound maintain stability up to 200 degrees C, although the ternary (3-CD/CUR/MTX demonstrated an initial mass loss at approximately 120 degrees C. Molecular docking studies indicated a strong binding affinity of (3-CD with both CUR and MTX driving by hydrogen bonding. DPPH radical scavenging assays demonstrated that the (3-CD/ CUR and (3-CD/CUR/MTX exhibited enhanced water solubility and antioxidant capacities compared to (3-CD and (3-CD/MTX. In vitro release studies revealed (3-CD/MTX displayed a controlled release behavior of MTX, achieving 80-95% within 120 min. Whereas CUR loaded (3-CD/CUR compound exhibited a rapid release of approximately 50% within 20 min. The release profile of (3-CD/CUR/MTX was significantly influenced by pH, in which the release at pH 5.3 was higher than that at pH 7.4, and exceeding 80% after 120 min. Importantly, the compounds ((3-CD/CUR and (3-CD/CUR/MTX) at a concentration of 80 & micro;M had a significant inhibitory cell viability and phagocytosed behavior on HepG2.
Keywords:
beta-Cyclodextrin
Curcumin
Methotrexate
Composite materials
Cytotoxicity
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4.7
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6.6W
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