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Face/off: phase-specific modeling of lineage plasticity using near-patient models in genitourinary cancers
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DOI：10.1016/j.gene.2026.150293.png)
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Abstract
En 中文
• Lineage plasticity is modeled as priming, transition, and stabilization. • Organoids reveal early, reversible plasticity and regulatory instability. • PDXs test which transitional states persist under in vivo constraints. • GEMMs define mechanisms enforcing stable lineage commitment • AI integrates multimodal data to map plasticity across model systems.