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Fat bolsters tumours against ferroptosis
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DOI：10.1038/s41556-026-01904-0.png)
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Abstract
En 中文
Tumour location dictates ferroptosis resistance. A study indicates that peritumoural adipose tissue aids tumours in evading ferroptosis by supplying tryptophan metabolites, including kynurenine and 3-hydroxykynurenine, which block NCOA4-mediated ferritinophagy to lower levels of labile iron and suppress lipid peroxidation.
Keywords:
Cancer immunotherapy
Cancer metabolism
Cancer microenvironment
Cell death
Life Sciences
general
Cell Biology
Cancer Research
Developmental Biology
Stem Cells
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19.1
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6.1K
Citations:
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