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Fatigue in bronchiectasis
DOI:10.1093/qjmed/hcr184.png)
Abstract
En 中文
Aim: To measure the correlation between FIS scores and markers of disease severity in nCF-Br. Design: A prospective cohort study. Methods: Patients attending a specialist service were studied. Lung function (FEV1% predicted), Medical Research Council dyspnoea score (MRCD), sputum culture results and FIS were recorded. Patients were categorized according to sputum culture into three subgroups: Pseudomonas 'colonization', 'isolation' and neither. Results: One hundred and seventeen consecutive patients were included. Average FEV1% predicted was 64% (SD +/- 28%). Twelve (10%) patients had Pseudomonas aeruginosa isolation; 47 (40%) patients had P. aeruginosa colonization. Fatigue levels were similar in patients with and without colonization (median 38 versus 32, P = 0.155). Significant fatigue (FIS > 40) was similar in all three Pseudomonas subgroups (P = 0.31, chi-square). Fatigue correlated with MRCD score (r = 0.57, P < 0.001) and FEV1% predicted (r = -0.30, P = 0.001). FEV1% predicted was lower in patients who had ever isolated or been colonized with P. aeruginosa (P 0.001). Conclusions: There are significant correlations between FIS score and MRCD score and FEV1% predicted in bronchiectasis. Pseudomonas aeruginosa infection appears to be associated with poorer lung function, and higher MRCD scores, yet there is no significant association between P. aeruginosa status and fatigue.
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