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Fatigue in bronchiectasis

delete2011-10-20
delete36
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OA
AI
K
Katy Hester
J
JG Macfarlane
H
H Tedd
H
Hannah Jary
P
Paul McAlinden
L
L. Rostron
T
Therese Small
J
Julia L. Newton
A
Anthony De Soyza *
DOI:10.1093/qjmed/hcr184delete
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Abstract

Abstract

En 中文
Aim: To measure the correlation between FIS scores and markers of disease severity in nCF-Br. Design: A prospective cohort study. Methods: Patients attending a specialist service were studied. Lung function (FEV1% predicted), Medical Research Council dyspnoea score (MRCD), sputum culture results and FIS were recorded. Patients were categorized according to sputum culture into three subgroups: Pseudomonas 'colonization', 'isolation' and neither. Results: One hundred and seventeen consecutive patients were included. Average FEV1% predicted was 64% (SD +/- 28%). Twelve (10%) patients had Pseudomonas aeruginosa isolation; 47 (40%) patients had P. aeruginosa colonization. Fatigue levels were similar in patients with and without colonization (median 38 versus 32, P = 0.155). Significant fatigue (FIS > 40) was similar in all three Pseudomonas subgroups (P = 0.31, chi-square). Fatigue correlated with MRCD score (r = 0.57, P < 0.001) and FEV1% predicted (r = -0.30, P = 0.001). FEV1% predicted was lower in patients who had ever isolated or been colonized with P. aeruginosa (P 0.001). Conclusions: There are significant correlations between FIS score and MRCD score and FEV1% predicted in bronchiectasis. Pseudomonas aeruginosa infection appears to be associated with poorer lung function, and higher MRCD scores, yet there is no significant association between P. aeruginosa status and fatigue.
Keywords:
QUALITY-OF-LIFE
FOLLOW-UP
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Journal

Q
QJM An International Journal of Medicine
IF:
6.4
Papers:
5.3K
Citations:
6.5K

Organization

N
newcastle university - uk
Scholars:
2.9W
Papers: 2.6W
Citations: 39
N
newcastle freeman hospital
Scholars:
2.2K
Papers: 1.7K
Citations: 1
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