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Fermented mycelial extract from Auricularia heimuer and Sparassis crispa mitigates cartilage degeneration and inflammation in monosodium iodoacetate-induced osteoarthritis
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DOI：10.1016/j.jff.2026.107387.png)
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Abstract
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• Fermentation enhanced steroidal saponin-associated metabolites in PS-ATJ301. • PS-ATJ301 improved weight-bearing capacity and joint structural integrity. • PS-ATJ301 suppressed MIA-induced inflammatory mediators, MMPs, and NF-κB signaling. • PS-ATJ301 promoted M2 polarization and regulated TLR4/MyD88/NF-κB/NLRP3 signaling.
Keywords:
Osteoarthritis
Monosodium iodoacetate
Fermented mushroom mycelium
Cartilage degeneration
NF-κB signaling
Macrophage polarization
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