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Ferroptosis Suppression by the M6A Reader IGF2BP1 Underlies Gemcitabine Resistance in Pancreatic Ductal Adenocarcinoma
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DOI：10.1002/advs.77048.png)
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Abstract
En 中文
Pancreatic ductal adenocarcinoma (PDAC) is a lethal malignancy with poor prognosis, and gemcitabine-based chemotherapy remains the standard first-line treatment. However, the rapid emergence of chemoresistance limits its efficacy. Elucidating the molecular mechanisms underlying gemcitabine resistance is critical for improving therapeutic outcomes.
Keywords:
ferroptosis
FTH1
IGF2BP1
N6-methyladenosine
pancreatic ductal adenocarcinoma
stress granule
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