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FGF signalling orchestrates multiple roles during salivary gland branching morphogenesis
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DOI：10.1016/j.ydbio.2026.04.008.png)
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Abstract
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• A combined approach comparing pharmaceutical inhibition and genetic deletion of Fibroblast Growth Factor Receptor (FGFR) highlights FGFR-specific changes in molecular signature during salivary gland branching morphogenesis. • Fibroblast Growth Factor (FGF) signalling influences the correct coordination of nerves and blood vessels with salivary gland epithelium. • FGF has a role in establishing tight junctions in salivary gland. • FGF signalling via ERK regulates the expression of the mature bud cell marker cKIT.
Keywords:
FGF signalling
salivary gland
branching morphogenesis
FGFR
cKIT
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