FGF20 alleviates neuroinflammation in ischemic stroke by modulating microglial polarization via TREM2-TLR4/NF-κB pathway

Liyun Zhu

doi:10.1016/j.cellimm.2026.105095

FGF20 alleviates neuroinflammation in ischemic stroke by modulating microglial polarization via TREM2-TLR4/NF-κB pathway

2026-03-08

0

PRE

AI

L

Liyun Zhu

S

Shufei Guo

Z

Zhengyi Wang

M

Min Huang

M

Mengfan Liu

L

Lixin Ruan

Y

Yuchi Zou *

L

Li Lin *

X

Xue Wang *

DOI：10.1016/j.cellimm.2026.105095

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Abstract

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• FGF20 alleviates neuroinflammation by modulating microglial M1/M2 polarization. • FGF20 upregulates TREM2 via FGFR1 and inhibits TLR4/NF-κB independently of FGFR1. • FGF20 extends its role to immunomodulation, highlighting therapeutic potential for stroke.

Keywords:

FGF20

neuroinflammation

microglial polarization

TREM2

TLR4/NF-κB pathway

FGF20 alleviates neuroinflammation in ischemic stroke by modulating microglial polarization via TREM2-TLR4/NF-κB pathway

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