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Fibroblast Growth Factor 8 Regulates Early Meckel’s Cartilage Development via ERK signaling in a Stage- and Dose-Dependent Manner
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DOI：10.1016/j.ydbio.2026.04.007.png)
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Abstract
En 中文
• Dynamic Fgf8 and receptor expression profiles define a specific regulatory window in early mandibular development. • FGF8 promotes mandibular cell expansion at E10 while simultaneously suppressing chondrogenic differentiation. • The pro-proliferative response to FGF8 is restricted to E10 and abolished at E11 due to an autonomous transcriptional shift. • FGF8-induced inhibition of Meckel’s cartilage formation is mediated by and dependent on the MEK/ERK signaling pathway. • FGF8 acts as a stage-specific regulator that coordinates the balance between cell proliferation and chondrogenic commitment.
Keywords:
FGF8
Meckel’s cartilage
ERK signaling
cell proliferation
chondrogenic differentiation
Journal
IF:
2.1
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393
Citations:
2.2W
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Cited Papers