.png){kind=icon}
.png){kind=icon}
Return
Fighting citrus Huanglongbing with evolutionary principles
.png){kind=icon}
PRE
AI
DOI：10.1016/j.tplants.2025.11.004.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Evolution-informed pest management (EIPM) leverages evolutionary principles to anticipate pest and pathogen adaptation, enabling durable crop protection. Evolutionary analysis identified a PUB21DN allele in resistant citrus relatives. PUB21DN functions as a loss-of-function allele that confers citrus resistance to Huanglongbing (HLB) by stabilizing MYC2 and activating plant immunity. In susceptible cultivars, a helitron element inserted into the PUB21 promoter enhances its expression and accelerates MYC2 degradation, thereby increasing HLB susceptibility. Artificial intelligence (AI) designed the micropeptide APP3-14, which works by inhibiting PUB21 to stabilize MYC2 and boost immunity, while also directly killing the Candidatus Liberibacter asiaticus (CLas). Integrating AI, synthetic biology, and gene editing offers a blueprint for developing biopesticides and HLB-resistant citrus cultivars.
Journal
IF:
20.8
Papers:
3.8K
Citations:
3.2W