.png){kind=icon}
.png){kind=icon}
Return
Finding the engram
.png){kind=icon}
PRE
AI
DOI：10.1038/nrn4000.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Many attempts have been made to localize the physical trace of a memory, or engram, in the brain. However, until recently, engrams have remained largely elusive. In this Review, we develop four defining criteria that enable us to critically assess the recent progress that has been made towards finding the engram. Recent 'capture' studies use novel approaches to tag populations of neurons that are active during memory encoding, thereby allowing these engram-associated neurons to be manipulated at later times. We propose that findings from these capture studies represent considerable progress in allowing us to observe, erase and express the engram.
Keywords:
LONG-TERM POTENTIATION
IMMEDIATE-EARLY GENE
MEMORY CONSOLIDATION
HIPPOCAMPAL REPLAY
EPISODIC MEMORY
SPATIAL MEMORY
SYNAPTIC PLASTICITY
ACTIVE NEURONS
VISUAL-CORTEX
GROWTH-FACTOR
AI Summary
Key information extracted from the uploaded paper, including a brief overview, abstract, background, key highlights, visual analysis, and future outlook.
Journal
IF:
26.7
Papers:
4.0K
Citations:
4.8W