.png){kind=icon}
.png){kind=icon}
Return
FKBP10 mitigates osteoporosis by restraining the HSPA5-coupled ERS-pyroptosis axis to enhance osteogenic differentiation in BMSCs
.png){kind=icon}
PRE
AI
D
H
Q
Y
Y
W
H
K
G
J
S
O
X
Y
D
Y
L
DOI：10.1016/j.intimp.2026.117031.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
• FKBP10 is downregulated in osteoporosis, and FKBP10 overexpression attenuates OVX-induced bone loss. • FKBP10 enhances osteogenic differentiation of BMSCs by increasing ALP activity and mineralization. • FKBP10 directly interacts with HSPA5 and promotes HSPA5 lysosomal degradation. • FKBP10 alleviates ERS-mediated pyroptosis to preserve the osteogenic capacity of BMSCs.
Journal
IF:
4.7
Papers:
1.6W
Citations:
4.1W
Organization
Cited Papers