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Fluid dynamic characterization and operating window analysis of a pilot-scale multiphase loop reactor for biotechnological applications
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DOI：10.1016/j.cherd.2026.06.054.png)
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Abstract
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• Pilot-scale MPLR established for fluid dynamic characterization. • Determination of key fluid dynamic parameters in two-phase operation: gas holdup, liquid velocity, volumetric mass transfer coefficient, mixing time. • Counter-current droplet transport was conservatively assessed using Schiller-Naumann, with partial validation in three-phase experiments. • A first-order operating window for future three-phase operation was derived.
Keywords:
Multiphase loop reactor
in situ product removal
Bioreactor
Bioprocess intensification
Pilot plant
Gas holdup
Aqueous velocities
Volumetric mass transfer parameter
Mixing time
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