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Fluorescent probes for liquid biopsy: Recent advances in clinical biofluid diagnostics
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DOI：10.1016/j.ccr.2026.218382.png)
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Abstract
En 中文
• Fluorescent probes for disease-related analysis of clinical biofluids. • Artificial biomarkers strategies for liquid biopsy applications. • Comparison of probe structures, sensing mechanisms, and performance. • Current challenges in POC and smartphone-based implementation. • Clinical-sample evaluation of fluorescent probes in biofluids.
Keywords:
Fluorescent probes
Liquid biopsy
Clinical biofluids
Artificial biomarkers
Point-of-care testing
Cys
,
Cysteine
Hcy
,
Homocysteine
GSH
,
Glutathione
sLeX
,
Sialyl Lewis X
CTSB
,
Cathepsin B
TILs
,
Tumor-infiltrating leukocytes
CTLs
,
Cytotoxic T lymphocytes
APN
,
Aminopeptidase N
NIR
,
Near-infrared
ARAR
,
Acute renal allograft rejection
GGT
,
γ-glutamyl transpeptidase
GzmB
,
Granzyme B
BUN
,
Blood urea nitrogen
O2•-
,
Superoxide anion
TICT
,
Twisted intramolecular charge transfer
AKI
,
Acute kidney injury
DTZ
,
Sodium diatrizoate
SCr
,
Serum creatinine
IBD
,
Inflammatory bowel disease
MB
,
Methylene blue
5-ASA
,
5-aminosalicylic acid
DSS
,
Dextran sulfate sodium
GBM
,
Glioblastoma
CES
,
Carboxylesterases
ICT
,
Intramolecular charge transfer
AD
,
Alzheimer's disease
PD
,
Parkinson's disease
CSF
,
Cerebrospinal fluid
ROS
,
Reactive oxygen species
RNS
,
Reactive nitrogen species
Aβ
,
Amyloid-β
ONOO−
,
Peroxynitrite
TPP
,
Triphenylphosphonium
BBB
,
Blood-brain barrier
MCI
,
Mild cognitive impairment
Mb
,
Myoglobin
Cyt c
,
Cytochrome c
MPO
,
Myeloperoxidase
H2O2
,
Hydrogen peroxide
ClO−
,
Hypochlorite
HOCl
,
Hypochlorous acid
LPS
,
Lipopolysaccharide
NE
,
Neutrophil elastase
PET
,
Photoinduced electron transfer
NAFLD
,
Non-alcoholic fatty liver disease
DPP4
,
Dipeptidyl peptidase-4
Glu
,
d-glucose
d
CKD
,
Chronic kidney disease
HSA
,
Human serum albumin
BSA
,
Bovine serum albumin
SLE
,
Systemic lupus erythematosus
BCG
,
Bromocresol green
eGFR
,
Estimated glomerular filtration rate
NADH
,
Nicotinamide adenine dinucleotide
ROC
,
Receiver operating characteristic
AUC
,
Area under the curve
NO
,
Nitric oxide
TB
,
Tuberculosis
Mtb
,
Mycobacterium tuberculosis
AI
,
Artificial intelligence
IrtAB
,
Iron-regulated transporter A and B
CFU
,
Colony-forming units
AO
,
Auramine O
POC
,
Point-of-care
POCT
,
Point-of-care testing
β-HB
,
β-hydroxybutyrate
Journal
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23.5
Papers:
8.9K
Citations:
7.3W
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