.png){kind=icon}
.png){kind=icon}
Return
Focused ultrasound blood brain barrier opening for targeted therapeutics in neurodegenerative diseases
.png){kind=icon}
PRE
AI
N
C
L
L
G
K
C
J
A
B
N
Y
DOI：10.1016/j.biopsych.2026.07.008.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Therapeutic focused ultrasound (FUS) leverages the non-invasive ultrasonic waves to modify the biological tissue. When administered alongside intravenous microbubbles, low-intensity FUS enables transient, targeted disruption of the blood-brain barrier (BBB), permitting passage of systemically administered therapeutics into the central nervous system (CNS) with high spatial precision. The ability to selectively modulate BBB permeability at the disease site has the potential to substantially expand the number of therapeutics that can be utilized in treating illnesses afflicting the CNS. Herein, we review the current applications of FUS for treating neurodegenerative disorders and diseases, including Alzheimer’s disease (AD), Parkinson’s disease (PD), and Amyotrophic lateral sclerosis (ALS). We discuss the research developments to date and future directions.
Journal
IF:
9
Papers:
1.5W
Citations:
4.0W
Organization
Cited Papers