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Forcing cell fate
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DOI：10.1038/s41556-025-01775-x.png)
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Abstract
En 中文
The transition of a pluripotent stem cell into a differentiated lineage is one of the most complex yet precisely orchestrated events in developmental biology. A study now reveals that mechanical and osmotic forces, long considered background players in guiding this transition, are essential regulators of chromatin accessibility and cell fate decisions.
Keywords:
pluripotent stem cell
chromatin accessibility
cell fate decision
mechanical forces
osmotic forces