1
Return

Foretinib triggers immunogenic cell death and enhances efficacy of anti-CD47 immunotherapy in colorectal cancer

delete2026-08-01
delete0
delete
OA
AI
L
Lin Li
N
Nannan Zhu
T
Tao Zhu
Y
Yuxuan Wang
J
Jieran Deng
H
Han Xie
X
Xiaoyun Guo
Q
Qianqian Duan *
L
Lei Chen *
J
Jingshan Tong *
X
Xiang Wang *
DOI：10.1016/j.neo.2026.101346delete
deleteOriginal
deleteOriginal request for help
deleteShare
deleteSave
Abstract

Abstract

En 中文
• The dual-target c-Met/VEGFR kinase inhibitor foretinib reshapes tumor immune microenvironment (TIME) by inducing immunogenic cell death (ICD). • We identified an on-target mechanism of foretinib in transcriptionally activating Drath Receptor 5 (DR5), a key component of the extrinsic apoptotic pathway. • The combination of foretinib with anti-CD47 antibody significantly inhibits tumor growth in colon cancer model.
Keywords:
Foretinib
ICD
CRC
CD47 blockade
Apoptosis

Journal

Neoplasia cover
Neoplasia
IF:
7.7
Papers:
2.8K
Citations:
8.0K

Organization

X
xuzhou medical university
Scholars:
1.5W
Papers: 7.2K
Citations: 158
Cited Papers

Cited Papers

Citing Papers

Citing Papers