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FOXC1 Controls Smooth Muscle Cell Differentiation and Plasticity in Vascular Disease
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DOI：10.1016/j.jacbts.2026.101566.png)
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Abstract
En 中文
• FOXC1 is a novel transcriptional regulator in atherosclerotic lesions, genetically linked with CAD and SMC-to-macrophage ratios in plaques, which warrants translational studies. • FOXC1 is down-regulated in plaques and intimal hyperplasia and localized to SMA+ cells. • FOXC1 regulates SMC quiescence vs activation by modulating key pathways involved in cell adhesion, cell cycle progression, and actin cytoskeleton organization.
Keywords:
atherosclerosis
BiKE
FOXC1
smooth muscle cells
AS
asymptomatic
CAD
coronary artery disease
FOXC1
Forkhead Box C1
MS
minor stroke
S
symptomatic
SMCs
smooth muscle cells
TFs
transcription factors
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