Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for effector Treg cell differentiation

Ryuichi Murakami

doi:10.1016/j.immuni.2026.03.005

Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for effector Treg cell differentiation

2026-03-30

0

PRE

AI

R

Ryuichi Murakami

N

Norihito Hayatsu

T

Takahisa Miyao

Z

Zhenan Liu

Y

Yukito Kino

S

Shumpei Shibata

S

Suzu Kawagoe

M

Masashi Matsuda

Y

Yusuke Iizuka

H

Hiroki Sugishita

H

Hideyuki Yoshida

Y

Yoshinori Hasegawa

W

Wataru Ise

H

Haruhiko Koseki

T

Tomohiro Kurosaki

S

Shohei Hori *

DOI：10.1016/j.immuni.2026.03.005

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Abstract

En 中文

• Foxp3 and BATF are jointly required for TCR-driven eTreg development • Foxp3 and BATF synergistically induce eTreg CREs and cis-regulatory programs • Chromatin accessibility is enhanced at eTreg CREs co-bound by Foxp3 and BATF • cTreg-specific Foxp3 binding is associated with reduced Tconv CRE accessibility

Keywords:

Foxp3

BATF

eTreg differentiation

cis-regulatory programs

chromatin accessibility

Foxp3 and BATF cooperatively direct cis-regulatory programs and gene expression for effector Treg cell differentiation

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