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Frailty assessed by comprehensive geriatric assessment and postoperative outcomes of older adults undergoing gastrectomy for gastric cancer
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DOI：10.1007/s00595-026-03281-5.png)
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Abstract
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Purpose Although surgical treatment can benefit older adults with gastric cancer (GC), the optimal surgical strategies for this population remain uncertain. We evaluated whether a 10-item frailty index based on comprehensive geriatric assessment (FI-CGA-10) could predict the postoperative outcomes of older adults undergoing gastrectomy for GC. Methods The subjects of this retrospective cohort study were patients aged >= 75 years who underwent CGA prior to curative gastrectomy. Patients were classified as fit, pre-frail, or frail according to FI-CGA-10 scores. We analyzed the associations between frailty status (frail vs. fit/pre-frail), screening tools, postoperative complications (Clavien-Dindo grade >= 2), treat-ment patterns, and follow-up outcomes. Results Among 79 patients, 18 were classified as frail and 61, as fit or pre-frail. Despite undergoing less extensive surgery, the frail group had more postoperative complications (50% vs. 23%, P = 0.032). Multivariable analysis showed that frailty was independently associated with complications (odds ratio = 4.86; 95% CI, 1.22-19.3; P = 0.025). The frail group also had longer hospitalizations, less adjuvant chemotherapy, and more frequent discontinuation of postoperative surveillance. Conclusion FI-CGA-10 was associated with postoperative complications in older adults undergoing gastrectomy for GC and may be useful for preoperative risk stratification
Keywords:
CGA
gastrectomy
complications
frailty
gastric cancer
older adults
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