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From Cytokines to Tuberculosis and Back: My Journey to Understanding the Immune Response to Infection

delete2025-04-25
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Anne O’Garra *
DOI:10.1146/annurev-immunol-010824-041601delete
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Abstract

Abstract

En 中文
I felt honored by the invitation to write this autobiography, although it was an arduous task to describe my journey through science: first bacterial adhesion, then cytokine function, and then immune responses in tuberculosis. Since only seven women had been authors of autobiographies for the Annual Review of Immunology, I felt I couldn't refuse to contribute to Volume 43 of the journal. Moreover, this was a good occasion to record my appreciation to all the lab members and collaborators for their contributions over the last 40 years, to remember the exciting times, and to reflect on the obstacles we faced. I often reflect on this line that is commonly attributed to Winston Churchill: Success is not final; failure is not fatal: It is the courage to continue that counts. What kept me going was a burning desire to know how things work and find enjoyment in the discovery. This passion to understand immune responses to infection remains with me to this day. I thank all those I have interacted with for the support and friendship they provided.
Keywords:
cytokine
T helper cells
Th1
Th2
macrophages
IL-10
dendritic cells
IL-12
tuberculosis
type I interferon
autobiography

Journal

Annual Review of Immunology cover
Annual Review of Immunology
IF:
33.3
Papers:
775
Citations:
2.0W

Organization

F
francis crick institute
Scholars:
545
Papers: 207
Citations: 87
Cited Papers

Cited Papers

Citing Papers

Citing Papers