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From human joints to bioreactor setups: Quantifying mechanical stimuli in cartilage physiology and regeneration
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DOI：10.1016/j.jmbbm.2026.107476.png)
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Abstract
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• Finite element models benchmarked bioreactors against knee joint mechanics. • Unconfined compression of osteochondral plugs matched physiological stresses in knee cartilage. • Tissue-engineered constructs experienced markedly sub-physiological stresses. • Findings of the study can guide physiologically relevant bioreactor design for cartilage studies.
Keywords:
Bioreactors
Knee joint mechanics
Osteochondral explants
Cartilage tissue engineering
Computational modeling
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