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From nanofiber biomimetics to multitarget bioactivities: Oligochitosan/polycaprolactone absorbable sutures via electrospinning-twisting integration

delete2026-05-08
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PRE
AI
J
Jiayi Jiang
R
Rongfeng Li
S
Shan Wang
M
Mohashin Kabir
L
Li Zhang
S
Shaohua Wu *
DOI：10.1016/j.bioadv.2026.214938delete
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Abstract

Abstract

En 中文
• Oligochitosan/polycaprolactone thread sutures with nanofiber-biomimetic structure were fabricated. • The OCS/PCL sutures exhibited over 99% antibacterial efficacy against both of E. coli and S. aureus. • The OCS addition could endow the sutures with high antioxidant activity and excellent hemocompatibility. • The OCS/PCL sutures possessed mechanical strength and knotting stability. • Molecular docking confirmed the multi-target and multi-mode binding of OCS to key wound healing regulators.
Keywords:
Oligochitosan
Polycaprolactone
Electrospinning
Wound healing
Antibacterial sutures

Journal

Biomaterials Advances cover
Biomaterials Advances
IF:
6
Papers:
1.9K
Citations:
6.0K

Organization

F
fudan university
Scholars:
11.3W
Papers: 7.6W
Citations: 121
Q
qingdao university
Scholars:
5.0K
Papers: 1.5K
Citations: 0
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