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From Primates to People: Mapping Host-Microbiome-Health Relationships in Aging
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DOI：10.1016/j.arr.2026.103278.png)
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Abstract
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• Microbial dysbiosis is associated with inflammaging and systemic decline. • Causality studies in humans are limited by ethical and logistical barriers. • Nonhuman primates (NHPs) provide a translational bridge to human studies. • Microbial taxa and aging microbial trajectories overlap between humans and NHPs. • Microbiome–immune–aging interactions can be rigorously tested in NHPs.
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