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From structural biology to precision medicine—decoding the key receptor in thyroid disorders
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DOI：10.1016/j.drudis.2026.104766.png)
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Abstract
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• Cryo-EM structures illuminate the ‘dual-key’ mechanism that allows TSHR to be activated by hormones and autoantibodies. • Functional antibody subtyping outperforms traditional binding assays for precise management of Graves‘ disease. • Blocking monoclonal antibody K1-70 exhibits thyroid function-suppressing efficacy in Phase I clinical trials. • Dual-target strategies that disrupt TSHR/IGF-1R crosstalk (e.g., teprotumumab) are beneficial in treating Graves’ orbitopathy.
Keywords:
Thyroid-stimulating hormone receptor (TSHR)
Thyroid disorders
Structural biology
G protein-coupled receptor (GPCR)
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