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From study design to executable code: automating target trial emulation with large language models

delete2026-07-09
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OA
AI
H
Hanjae Kim, BS
M
Minseong Kim, BS
S
Seonji Kim
S
Seng Chan You *
DOI:10.1093/jamiaopen/ooag131delete
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Abstract

Abstract

En 中文
Implementing target trial emulation (TTE) studies as standardized, reproducible analytic workflows is technically demanding. We developed Text-guided Health-study Estimation and Specification Engine Using Strategus (THESEUS), which uses large language models (LLMs) to translate free-text study descriptions into structured analytic specifications and Strategus R scripts within the Observational Health Data Sciences and Informatics (OHDSI) ecosystem.

Journal

J
JAMIA Open
IF:
3.4
Papers:
379
Citations:
1.7K

Organization

Y
Yonsei University College of Medicine
Scholars:
2.0K
Papers: 656
Citations: 1
Cited Papers

Cited Papers

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Comparative estimation of the effects of antihypertensive medications on schizophrenia occurrence: a multinational observational cohort study
err2024-02-16
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errOAAI
errLee, Dong Yun; Kim, Chungsoo; Kim, Jiwoo; Yun, Jeongwon; Lee, Yujin; Chui, Celine Sze Ling; Son, Sang Joon; Park, Rae Woong; You, Seng Chan
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Comparative Effectiveness of Second-Line Antihyperglycemic Agents for Cardiovascular Outcomes A Multinational, Federated Analysis of LEGEND-T2DM
err2024-09-01
err5
PREAI
errDhingra, Lovedeep Singh; Thangaraj, Phyllis M.; Camargos, Aline Pedroso; Bu, Fan; Ding, Xiyu; Nishimura, Akihiko; Anand, Tara V.; Arshad, Faaizah; Blacketer, Clair; Chattopadhyay, Shounak; Cook, Michael; Dorr, David A.; Duarte-Salles, Talita; DuVall, Scott L.; Falconer, Thomas; French, Tina E.; Hanchrow, Elizabeth E.; Kaur, Guneet; Lau, Wallis C. Y.; Li, Jing; Li, Kelly; Liu, Yuntian; Lu, Yuan; Man, Kenneth K. C.; Matheny, Michael E.; Mathioudakis, Nestoras; McLeggon, Jody-Ann; McLemore, Michael F.; Minty, Evan; Morales, Daniel R.; Nagy, Paul; Ostropolets, Anna; Pistillo, Andrea; Reyes, Carlen; Richter, Lauren; Ross, Joseph S.; Ruan, Elise; Seager, Sarah L.; Simon, Katherine R.; Viernes, Benjamin; Yang, Jianxiao; Yin, Can; Zhou, Jin J.; Ryan, Patrick B.; Schuemie, Martijn J.; Krumholz, Harlan M.; Hripcsak, George; Suchard, Marc A.
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Effect of erythromycin on mortality and the host response in critically ill patients with sepsis: a target trial emulation
err2022-05-24
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errReijnders, Tom D. Y.; Peters-Sengers, Hessel; van Vught, Lonneke A.; Uhel, Fabrice; Bonten, Marc J. M.; Cremer, Olaf L.; Schultz, Marcus J.; Stuiver, Martijn M.; van der Poll, Tom
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