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From study design to executable code: automating target trial emulation with large language models

delete2026-07-09
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OA
AI
H
Hanjae Kim, BS
M
Minseong Kim, BS
S
Seonji Kim
S
Seng Chan You *
DOI:10.1093/jamiaopen/ooag131delete
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Abstract

Abstract

En 中文
Implementing target trial emulation (TTE) studies as standardized, reproducible analytic workflows is technically demanding. We developed Text-guided Health-study Estimation and Specification Engine Using Strategus (THESEUS), which uses large language models (LLMs) to translate free-text study descriptions into structured analytic specifications and Strategus R scripts within the Observational Health Data Sciences and Informatics (OHDSI) ecosystem.

Journal

J
JAMIA Open
IF:
3.4
Papers:
331
Citations:
1.7K

Organization

Y
Yonsei University College of Medicine
Scholars:
1.9K
Papers: 596
Citations: 1