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From voxel discovery to regional interaction: A multi-level interpretable framework for Alzheimer’s disease diagnosis
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DOI：10.1016/j.media.2026.104243.png)
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Abstract
En 中文
• A multi-level framework bridges voxel signals to networks for transparent diagnosis. • Gradient-guided EM-like HiEM actively isolates high-fidelity digital biomarkers. • Dynamic parcellation and topology modeling reconstruct pathological trajectories. • Superior anatomical specificity over post-hoc methods validates biomarker discovery.
Keywords:
Multi-level interpretable
Voxel discovery
Regional interaction
Alzheimer’s disease
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