.png){kind=icon}
.png){kind=icon}
Return
Fucoidan/bis-MPA-based dendrimer nanoparticles with intrinsic anti-angiogenic activity for oncology applications
.png){kind=icon}
OA
AI
DOI：10.1039/d5pm00362h.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
Nanoparticles with intrinsic anti-angiogenic activity hold strong promise in cancer nanomedicine, as they can both help suppress metastasis and deliver therapeutics, offering a dual strategy for addressing the disease. In this study, fucoidans from F. vesiculosus and U. pinnatifida with two different molecular weights (MW) of each were initially screened for in vitro anti-angiogenic potential using the tube formation assay with HUVEC cells. The higher MW fucoidans, which represent native MW fucoidan, exhibited greater anti-angiogenic activity and were subsequently combined with 2,2-bis(hydroxymethyl)propionic acid (bis-MPA)-based dendrimers (generation 2) at different fucoidan/dendrimer (F/D) mass ratios to form self-assembled nanoparticles through electrostatic interactions. Optimisation yielded two nanoparticle types with positive (F/D = 1 : 2) and negative (F/D = 2 : 1) zeta potentials, which were characterised for their physicochemical properties, including hydrodynamic diameter, zeta potential, chemical composition (FTIR), and morphology (TEM). These nanoparticles presented a near-spherical shape, were cytocompatible, and did not cause haemolysis. Positively charged nanoparticles showed stronger anti-angiogenic activity than negatively charged ones. Since the dendrimers alone were also anti-angiogenic, the overall effect likely results from the combined contribution of both components, with nanoparticle assembly potentially playing a role. Overall, these findings highlight the potential of fucoidan/dendrimer nanoparticles as multifunctional platforms for cancer nanomedicine, by targeting angiogenesis and potentially serving as drug or gene delivery systems.
Keywords:
POLYESTER DENDRIMERS
BIS-MPA
Journal
R
IF:
0
Papers:
68
Citations:
0
