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Functional characterization of a plant germacrene D-4-ol synthase enabling the production of bioactive α-cadinol and τ-muurolol under changed catalysis conditions
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DOI：10.1016/j.phytochem.2026.114945.png)
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Abstract
En 中文
• Functional characterization of a germacrene D-4-ol synthase (CcTPS3) from C. coccinea var. mollis. • The product profile of CcTPS3 is host dependent and is influenced by variations in pH • Engineered E. coli achieved titers of 35 mg/L α-cadinol and 17 mg/L τ-muurolol. • Found that τ-muurolol and α-cadinol possess lipid-lowering activity.
Keywords:
CcTPS3
α-cadinol
τ-muurolol
host-dependent catalysis
lipid-lowering activity
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3.4
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1.3W
Citations:
3.2W
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