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Functional status in COPD: Comparison with healthy controls and impact of an exacerbation

delete2025-07-08
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OA
AI
F
Fien Hermans
E
Eva Arents
A
Astrid Blondeel
N
Nina Cardinaels
W
Wim Janssens
T
Thierry Troosters
E
Eric Derom
H
Heleen Demeyer
DOI：10.1177/14799731251358593delete
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Abstract

Abstract

En 中文
<jats:sec> <jats:title>Background</jats:title> <jats:p>Functional status is a marker for evaluating fall risk and predicting mortality and hospitalisations in elderly and patients with COPD. Acute exacerbations of COPD result in sudden declines in exercise capacity, quadriceps force (QF) and physical activity (PA), but their impact on functional status remains unclear. This study aimed to (i) compare the functional status of patients with COPD to healthy controls and (ii) assess prospectively the impact of an exacerbation on functional status.</jats:p> </jats:sec> <jats:sec> <jats:title>Methods</jats:title> <jats:p>Healthy controls and patients were assessed. Patients were followed up every 6 months and were tested again immediately if they reported an exacerbation. The short physical performance battery (SPPB), timed up and go test (TUG), 1-minute sit-to-stand test (1MSTS), 6-minute walking distance (6MWD), QF and PA (accelerometery) were measured.</jats:p> </jats:sec> <jats:sec> <jats:title>Results</jats:title> <jats:p>Thirty-six patients (69 ± 7 years, 69% male) and 25 matched healthy controls (68 ± 7 years, 80% male) were included. Functional status was decreased in patients compared to healthy controls. Twelve patients were retested 10 ± 7 days after a moderate (n = 11) or severe (n = 1) exacerbation. The 1MSTS (∆-3 ± 3repetitions, p &lt; 0.0001), 6MWD (∆-34 ± 46m, p &lt; 0.0001) and QF (∆-9 ± 13Nm, p = 0.05) decreased after exacerbation onset. No changes in SPPB and PA were observed.</jats:p> </jats:sec> <jats:sec> <jats:title>Conclusion</jats:title> <jats:p>An exacerbation negatively impacts the already reduced functional status in patients with COPD. The SPPB is not able to capture this decline.</jats:p> </jats:sec>
Keywords:
chronic obstructive pulmonary disease
functional status
acute exacerbation
physical performance
quadriceps force

Journal

C
Chronic Respiratory Disease
IF:
2.3
Papers:
685
Citations:
1.5K

Organization

No organization information available