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Fusion gene heterogeneity and kinase enrichment in high-grade serous carcinomas

delete2026-06-25
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OA
AI
I
Ioannis Panagopoulos
A
Ane Stranger
A
Anita Sveen
M
Mie Jareid
S
Susanne G. Kidd
K
Katharina Bischof
K
Kjetil Taskén
A
Anne Dørum
B
Ben Davidson
R
Ragnhild A. Lothe
R
Rolf I. Skotheim
B
Bjarne Johannessen *
DOI：10.1016/j.neo.2026.101332delete
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Abstract

Abstract

En 中文
• Multi-site RNA sequencing reveals fusion gene heterogeneity in tubo-ovarian cancer. • Most fusion genes are nonrecurrent and unique to individual cancers. • Protein kinases are significantly enriched among fusion partners. • Several kinase fusions retain intact catalytic domains. • Fusion genes and HRD alterations broaden homologous recombination involvement.
Keywords:
High-grade serous tubo-ovarian carcinoma
Fusion gene heterogeneity
RNA sequencing
Kinase enrichment
Homologous recombination deficiency

Journal

Neoplasia cover
Neoplasia
IF:
7.7
Papers:
2.8K
Citations:
8.0K

Organization

O
oslo university hospital-radiumhospitalet
Scholars:
12
Papers: 2
Citations: 0
U
University of Oslo
Scholars:
2.9K
Papers: 1.3K
Citations: 0
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