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GABA promotes resistance to immunotherapy in patients with TLS-positive tumors

delete2026-07-09
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PRE
AI
I
Isaias Hernández-Verdin
A
Anne Calvez
C
Cheng-Ming Sun
A
Antoine Bougoüin
P
Pierre Hirt
E
Eric Pinaud
M
Matthew J. Smith
C
Craig E. Wheelock
V
Virginie Verkarre
Y
Yann-Alexandre Vano
L
Lucie Garnier
T
Théo Bouloudani
G
Guilhem Pupier
D
Dahbia Djaroun
C
Christian Wu
A
Asmat Ullah
L
Lucile Vanhersecke
A
Alban Bessede
J
Jean-Philippe Guegan
L
Laurence Albiges
DOI：10.1016/j.ccell.2026.06.006delete
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Abstract

Abstract

En 中文
• GABA signatures correlate with resistance to immunotherapy in TLS-containing tumors • In resistant patients, TLSs close to GABA-producing tumor cells are dysfunctional • In vitro, GABA inhibits B cell maturation and differentiation to Ig producing cells • In vivo, GABA blockade increases anti-PD1 response and B cell densities inside TLSs

Journal

Cancer Cell cover
Cancer Cell
IF:
44.5
Papers:
413
Citations:
5.6W

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