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GABA promotes resistance to immunotherapy in patients with TLS-positive tumors
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DOI：10.1016/j.ccell.2026.06.006.png)
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Abstract
En 中文
• GABA signatures correlate with resistance to immunotherapy in TLS-containing tumors • In resistant patients, TLSs close to GABA-producing tumor cells are dysfunctional • In vitro, GABA inhibits B cell maturation and differentiation to Ig producing cells • In vivo, GABA blockade increases anti-PD1 response and B cell densities inside TLSs
Journal
IF:
44.5
Papers:
413
Citations:
5.6W
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