.png){kind=icon}
.png){kind=icon}
Return
Galectin-1 Is a Marker but Not a Mediator of Heart Failure With Preserved Ejection Fraction
.png){kind=icon}
PRE
AI
C
F
M
P
Z
M
W
S
S
S
K
G
A
M
DOI：10.1161/HYPERTENSIONAHA.125.26006.png)
.png){kind=icon}
Original request for help.png){kind=icon}
Share.png){kind=icon}
Save
Abstract
En 中文
BACKGROUND:The immune system is emerging as a key player in driving cardiac remodeling in heart failure with preserved ejection fraction (HFpEF). Galectin-1 (Lgals1) is a carbohydrate-binding protein that we previously identified as being upregulated in cardiac myeloid cells in a preclinical model of HFpEF. Our objective was to determine the role of galectin-1 in HFpEF in both preclinical models and clinical cohort studies.METHODS:Galectin-1 was measured using the Olink proximity extension assay in human cohorts. HFpEF was induced in mice with myeloid-specific and global deletion of galectin-1 and corresponding controls using the hypertensive deoxycorticosterone acetate-salt model.RESULTS:Plasma galectin-1 was higher in both a preclinical model of HFpEF (P=0.022) and in patients with heart failure (P < 0.001) in the UK Biobank. In patients without heart failure, higher galectin-1 levels were associated with a greater risk for incident heart failure (hazard ratio, 3.1 for quartile 4 versus quartile 1; P < 0.001). In patients with acute HFpEF, galectin-1 was positively associated with NT-proBNP (N-terminal pro-B-type natriuretic peptide), a biomarker of worse prognosis (ordinal regression P < 0.001). Mice with myeloid cell or global deficiency of galectin-1, however, exhibit no difference in deoxycorticosterone acetate-salt-induced HFpEF.CONCLUSIONS:Greater circulating galectin-1 levels are associated with a higher risk of incident heart failure and higher NT-proBNP among patients with acute HFpEF. However, neither global nor myeloid deficiency of galectin-1 altered the cardiovascular phenotype in a preclinical model of HFpEF, suggesting that it is a marker but not a causal mediator of the disease.
Keywords:
heart failure
inflammation
macrophages
galectin-1
Journal
IF:
8.2
Papers:
1.6W
Citations:
4.0W
Organization
Cited Papers