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Ganoderic acid A accelerates osteoporotic fracture healing by promoting osteogenic differentiation via estrogen receptor alpha binding
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DOI:10.1016/j.jot.2026.101173.png)
Abstract
En 中文
Ganoderic acid A (GAA), a natural triterpenoid derived from the fungal species Ganoderma lucidum which is known for its medicinal properties, is well recognized for its anti-inflammatory, anti-aging, kidney-protective, and hepatoprotective properties. However, its role in osteoporotic fracture (OF) healing remains unclear.This study aims to explore the pharmacological effects of GAA on OF healing and to clarify its underlying mechanisms.
Keywords:
Bone formation
Bone resorption
Estrogen receptor alpha
Ganoderic acid A
Osteogenic differentiation
Osteoporotic fractures
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